Which factor is not associated with greater suspicion in cases of nipple discharge?

The factor associated with greater suspicion in cases of nipple discharge is often the nature of the discharge and the circumstances under which it occurs. Spontaneous discharge, which occurs without any physical stimulation, tends to raise concern and warrant further investigation. Discharges that are clear or bloody can be indicative of underlying pathology, including malignancy, especially when they are unilateral.

Unilateral discharge, meaning it occurs from one breast rather than both, is particularly significant because it can suggest localized pathological processes, including tumors or other conditions associated with cancer risk. On the other hand, discharge from multiple ducts tends to be less suggestive of malignancy. This is because pathological conditions, especially those related to ductal carcinoma, usually involve single ducts rather than multiple ones.

Therefore, when considering factors that signal greater suspicion for a serious condition, the involvement of multiple ducts does not typically align with those concerns, making it the correct choice in this context.