Which technology employs 3D imaging of the breast with isotropic imaging?

The technology that employs 3D imaging of the breast with isotropic imaging is coned beam breast CT. This imaging modality utilizes a cone-shaped x-ray beam to acquire volumetric data of the breast, capturing a three-dimensional representation that allows for isotropic imaging—meaning the resolution is uniform in all directions. This capability enhances the visualization of breast anatomy and lesions, providing clearer and more detailed images compared to traditional 2D mammography.

Digital Breast Tomosynthesis (DBT) also produces 3D images; however, it does so through a series of 2D images taken at various angles that are reconstructed digitally. The isotropic imaging aspect is not inherent to DBT in the way it is to coned beam breast CT. Automated Breast Ultrasound System (ABUS) is another advanced imaging technique but does not function through isotropic imaging nor is it based on the x-ray technology that characterizes the previous two.

Thus, while other modalities offer 3D capabilities, coned beam breast CT stands out specifically for its isotropic imaging feature, making it the correct answer.