To avoid any possibility of confusion, the location of an ROI should be described by:

The most comprehensive way to ensure clarity in describing the location of a region of interest (ROI) in mammography is to utilize a clock face reference. When using the clock time method, healthcare professionals can pinpoint the exact area of concern on the breast. For example, indicating that an ROI is located at "2 o'clock" provides a specific location relative to the perceived orientation of the breast, which helps eliminate ambiguity.

This technique is especially useful because it allows for a standardized communication method among radiologists and other healthcare professionals, reducing the risk of misinterpretation regarding the location of abnormalities. By describing the location using this method, combined with the recognition that positioning within breast quadrants or identifying the breast as right or left can still leave some room for miscommunication, the clock time approach emerges as the most clear and efficient method.